Pharmacology

Drug Information

Physostigmine vs. neostigmine

 

LMNOP:

Lipid soluble
Miotic
Natural
Orally absorbed well
Physostigmine
· Neostigmine, on the contrary, is:
Water soluble
Used in myesthenia gravis
Synthetic
Poor oral absorption

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Steroid side effects

CUSHING OID:

Cataracts
Ulcers
Skin: striae, thinning, bruising
Hypertension/ Hirsutism/ Hyperglycemia
Infections
Necrosis, avascular necrosis of the femoral head
Glycosuria
Osteoporosis, obesity
Immunosuppression
Diabetes

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Beta blockers with CYP2D6 polymorphic metabolism “I Met

Tim Carver, the metabolic polymorph”:
· The following beta blockers require dose adjustment due to CYP2D6 polymorphic
metabolism:
Metoprolol
Timolol
Carvedilol
(in patients with lower or higher than normal CYP2D6 activity)

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Beta blockers with intrinsic sympathomimetic activity

Picture diabetic and asthmatic kids riding away on a cart
that rolls on pinwheels.

Pindolol and Carteolol have high and moderate ISA respectively,
making them acceptable for use in some diabetics or asthmatics despite the fact
that they are non-seletive beta blockers.

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Amiodarone: action, side effects 6 P’s:

Prolongs action potential duration
Photosensitivity
Pigmentation of skin
Peripheral neuropathy
Pulmonary alveolitis and fibrosis
Peripheral conversion of T4 to T3 is inhibited -> hypothyroidism

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Morphine effects 

MORPHINES:

Miosis
Orthostatic hypotension
Respiratory depression
Pain supression
Histamine release/ Hormonal alterations
Increased ICT
Nausea
Euphoria
Sedation

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