Pharmacology

Newer Drugs….!!

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NEWER DRUGS 2015:

Edoxaban – Oral factor Xa inhibitor approved for DVT, pulmonary embolism and stroke prophylaxis in atrial fibrillation.
• Secukinumab – Anti IL 17 Ab approved for Psoriasis
• Isavuconazonium – Azole approved for invasive Aspergillosis and mucormycosis

• Avibactam – With Ceftazidime

• Panobinostat – Histone deacetylase inhibitor for multiple myeloma.

• Cobicistat – Its a CYP3A4 inhibitor approved for use with Atazanavir and Darunavir to increase their half life.

• Palbociclib – Cyclin dependent kinase inhibitor approved for ER/PR positive breast in post menopausal female in combination with aromatase inhibitor.

• Lenvatinib – VEGFR TK inhibitor approved for recurrent or metastatic thyroid ca refractory to I131.

• Nivolumab – Anti PD1 receptor Ab approved for metastatic squammous non small cell ca lung.

• Dinutuximab – Anti GD2 glycolipid Ab approved for neuroblastoma.

• Ivabridine – Inhibitor of If current in SA node… Approved for CHF and angina.

• Sacubitril – Inhibitor of neutral endopeptidase (neprilysin), combined with ARB for treatment of CHF.

• Alirocumab – Anti PCSK 9 Ab used to decrease LDL in familial hypercholesterolemia and CVS atherosclerotic disorders. PCSK 9 is a protein responsible for LDL receptors degradation in liver.

• Sonidegib – Hedgehog pathway inhibitor used for treatment of basal cell carcinoma recurrence after surgery and radiotherapy.

• Flibanserin – 5HT 1A agonist and 5HT 2C antagonist for hypoactive sexual desire disorder (HSDD).

• Paritaprevir – It is a Hep C virus protease inhibitor.

•Daclatasvir, Ombitasvir – NS5A protein inhibitors of hep C virus.
1. Daclatasvir is approved to be used with sofosbuvir for Hep C infection.
2. Ombitasvir is approved to be used with paritaprevir and ritonavir for Hep C virus infection.

• Brexpiprazole – Atypical antipsychtic approved for treatment of schizophrenia and depression.

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