For Updates follow us on: Facebook.com/PGMEEQuest ——————————————- NEWER DRUGS 2015: Edoxaban – Oral factor Xa inhibitor approved for DVT, pulmonary embolism and stroke prophylaxis in atrial fibrillation. • Secukinumab – Anti IL 17 Ab approved for Psoriasis • Isavuconazonium – Azole approved for invasive Aspergillosis and mucormycosis • Avibactam – With Ceftazidime • Panobinostat –… Continue reading Newer Drugs….!!
Update of New Drugs & DOC with Reference :- REFERNCE: Harrisons 19/ed Adams Neurology 10/ed CMDT 2015 Williams OBG 24/Ed Mania Treatment Update: 1. DOC Acute Mania – Atypical AP (Bzd may be used for symptomatic management) 2. Prophylaxis of mania – Lithium 3. DOC BPD – Lithium 4. DOC Rapid Cycler – Valproate *Lithium… Continue reading PHARMACOLOGY: New Drugs Update
PGM-CET PHARMACOLOGY :- Newer Drugs ? ? Avibactam -Beta Lactamase Inhibitor ?Cobicistat -Enzyme inhibitor CYP3A4 -Booster with PIs ?Peramivir – Neuraminidase Inhibitoy – Influenza A & B ? Simeprevir -Inhibitor of NS3/4A Protease of Hep.C -Hepatitis C ?Bedaquiline -Mycobact. ATP synthase inhibitor -MDR Tb ?Dolutegravir -Integrase inhibitor -Hiv ?Affreza -Inhalational Insulin -Ty.1 DM a/w Long… Continue reading PHARMACOLOGY :-Newer Drugs ?
Anatomy Cranial duramater has periosteal and meningeal layers, is supplied by 5th nerve, is outermost meningeal layer and Dural venous sinuses are not present inner to the meningeal layer. Lateral pterygoid muscle, medial pterygoid muscle and tensor veli palatini muscle are innervated by trigeminal nerve. Stylohyoid muscle is innervated by the stylohyoid branch of the… Continue reading AIIMS MAY 2014 with Solutions
?PHARMACOLOGY UPDATE: ?First-in-class drug for HF approved?: Time to replace ACE inhibitors ?Approval of the first angiotensin-receptor/neprilysin inhibitor (ARNI): valsartan/sacubitril for the treatment of heart failure with reduced ejection fraction (HFrEF) ?PARADIGM-HF* trial results last year which showed that valsartan/sacubitril (formerly called LCZ696) significantly reduced the risk of cardiovascular (CV) death and hospitalization for HF… Continue reading First-in-class drug for HF approved?
FDA pushed out 4 big approvals. Cholesterol-reducing PCSK9 inhibitors: Sanofi and Regeneron’s Praluent Technivie (ombitasvir, paritaprevir and ritonavir) for Chronic Hepatitis C Genotype 4 Infections Odomzo (sonidegib), a hedgehog pathway inhibitor for basal cell carcinoma Kyprolis (carfilzomib) for Combination Treatment of Patients with Relapsed Multiple Myeloma Praluent (alirocumab) to Treat Certain Patients with High Cholesterol Daklinza (daclatasvir) for… Continue reading Drugs Update: New FDA approved Drugs
Methyldopa: side effects METHYLDOPA: Mental retardation Electrolyte imbalance Tolerance Headache/ Hepatotoxicity psYcological upset Lactation in female Dry mouth Oedema Parkinsonism Anaemia (haemolytic) **************************** Refer Books: Katzung Pharmacology KDT Pharmacology Classification of Drugs Vikas Seth
Ca++ channel blockers: uses CA++ MASH: Cerebral vasospasm/ CHF Angina Migranes Atrial flutter, fibrillation Supraventricular tachycardia Hypertension · Alternatively: “CHASM“: Cererbral vasospasm / CHF Hypertension Angina Suprventricular tachyarrhythmia Migranes
Physostigmine vs. neostigmine LMNOP: Lipid soluble Miotic Natural Orally absorbed well Physostigmine · Neostigmine, on the contrary, is: Water soluble Used in myesthenia gravis Synthetic Poor oral absorption ***************************************************************** Steroid side effects CUSHING OID: Cataracts Ulcers Skin: striae, thinning, bruising Hypertension/ Hirsutism/ Hyperglycemia Infections Necrosis, avascular necrosis of the femoral head Glycosuria Osteoporosis, obesity Immunosuppression Diabetes… Continue reading Drug Information
Phenytoin adverse effects PHENYTOIN: P-450 interactions Hirsutism Enlarged gums Nystagmus Yellow-browning of skin Teratogenicity Osteomalacia Interference with B12 metabolism (hence anemia) Neuropathies: vertigo, ataxia, headache